From BioMEMS to Bionanotechnology: Integrated BioChips for the Detection of Cells and Microorganisms

R. Bashir, D. Akin, R. Gómez, H. Li, W. J. Chang, A. Gupta

Research output: Contribution to journalConference articlepeer-review


This paper reviews the interdisciplinary work performed in our group in recent years to develop micro-integrated devices to characterize biological entities. We present the use of electrical and mechanically based phenomena to perform characterization and various functions needed for integrated biochips. One sub-system takes advantage of the dielectrophoretic effect to sort and concentrate cells within a micro-fluidic biochip. Another sub-system measures impedance changes produced by the metabolic activity of cells to determine their viability. A third sub-system is used to detect the mass of bacteria as they bind to micro-mechanical silicon cantilevers. These devices with an electronic signal output can be very useful in producing practical systems for rapid detection and characterization of cells for a wide variety of applications in the food safety and health diagnostics industries.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalMaterials Research Society Symposium - Proceedings
StatePublished - 2003
Externally publishedYes
EventBiomicroelectromechanical Systems (BioMEMS) - San Francisco, CA, United States
Duration: Apr 22 2003Apr 25 2003

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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