Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR

Ru Xin Li, Xin Zhu Yu, Min Fu, Min Zong, Ru Lin Liu, Zuo Ping Xie

Research output: Contribution to journalArticlepeer-review

Abstract

The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultured hippocampal neurons, we found that rapamycin significantly reduces the spontaneous activities of network neurons as well as the efficacy of synaptic transmission through insulin-mTOR signaling pathway. Our study sheds light on understanding the role of mTOR signaling pathway in controlling the information processing of network neurons.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalNeuroscience Letters
Volume441
Issue number1
DOIs
StatePublished - Aug 15 2008
Externally publishedYes

Keywords

  • Ca spike
  • Insulin
  • Rapamycin
  • mTOR

ASJC Scopus subject areas

  • General Neuroscience

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