Fragile X mental retardation protein and synaptic plasticity

Michael S. Sidorov; Benjamin D. Auerbach; Mark F. Bear

doi:10.1186/1756-6606-6-15

Fragile X mental retardation protein and synaptic plasticity

Michael S. Sidorov, Benjamin D. Auerbach, Mark F. Bear

Research output: Contribution to journal › Review article › peer-review

Abstract

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

Original language	English (US)
Article number	15
Journal	Molecular Brain
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/1756-6606-6-15
State	Published - 2013
Externally published	Yes

Keywords

FMRP
Fragile X
Long-term depression
Long-term potentiation
Metabotropic glutamate receptor
Protein synthesis
Synaptic plasticity

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Online availability

10.1186/1756-6606-6-15

Library availability

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abstract = "Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.",

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AU - Auerbach, Benjamin D.

AU - Bear, Mark F.

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AB - Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

KW - FMRP

KW - Fragile X

KW - Long-term depression

KW - Long-term potentiation

KW - Metabotropic glutamate receptor

KW - Protein synthesis

KW - Synaptic plasticity

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Fragile X mental retardation protein and synaptic plasticity

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

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