Fragile X mental retardation protein and synaptic plasticity

Michael S. Sidorov, Benjamin D. Auerbach, Mark F. Bear

Research output: Contribution to journalReview articlepeer-review


Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

Original languageEnglish (US)
Article number15
JournalMolecular Brain
Issue number1
StatePublished - 2013
Externally publishedYes


  • FMRP
  • Fragile X
  • Long-term depression
  • Long-term potentiation
  • Metabotropic glutamate receptor
  • Protein synthesis
  • Synaptic plasticity

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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