Abstract
Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.
Original language | English (US) |
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Article number | 15 |
Journal | Molecular Brain |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - 2013 |
Externally published | Yes |
Keywords
- FMRP
- Fragile X
- Long-term depression
- Long-term potentiation
- Metabotropic glutamate receptor
- Protein synthesis
- Synaptic plasticity
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience