Fourier transform light scattering of tissues

Taewoo Kim, Shamira Sridharan, Gabriel Popescu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We review the basic principles of light-tissue interaction and common methods of investigation. The mathematical framework for describing weakly scattering regime (the Born approximation) as well as the strong scattering regime (the diffusion equation) are described. Traditional techniques based on polarization, time-resolved, single and multiple scattering are reviewed. We then introduce Fourier transform light scattering (FTLS), which is a recent development from our own laboratory. FTLS is the spatial analogue of Fourier transform spectroscopy, in the sense that it provides angular scattering (spatial frequency) data from phase and amplitude measurements in the spatial (image) domain. We show that FTLS can be used as a diagnostic tool by translating the quantitative phase information into data of clinical relevance. Further, FTLS allows us to extract scattering parameters of the tissue from imaging unlabeled, thin tissue slices, using a relationship which we call the scattering-phase theorem. Using these measurements, FTLS can predict the outcome of many other experiments, including time resolved and enhanced backscattering experiments.

Original languageEnglish (US)
Title of host publicationHandbook of Coherent-Domain Optical Methods: Biomedical Diagnostics, Environmental Monitoring, and Materials Science:: Second Edition
PublisherSpringer New York
Pages259-290
Number of pages32
Volume1-2
ISBN (Electronic)9781461451761
ISBN (Print)9781461451754
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Kim, T., Sridharan, S., & Popescu, G. (2013). Fourier transform light scattering of tissues. In Handbook of Coherent-Domain Optical Methods: Biomedical Diagnostics, Environmental Monitoring, and Materials Science:: Second Edition (Vol. 1-2, pp. 259-290). Springer New York. https://doi.org/10.1007/978-1-4614-5176-1_7