Fourier transform light scattering (FTLS) of cells and tissues

Huafeng Ding; Zhuo Wang; Freddy T. Nguyen; Stephen A. Boppart; Larry J. Millet; Martha U. Gillette; Jianming Liu; Marni D. Boppart; Gabriel Popescu

doi:10.1166/jctn.2010.1637

Fourier transform light scattering (FTLS) of cells and tissues

Huafeng Ding, Zhuo Wang, Freddy T. Nguyen, Stephen A. Boppart, Larry J. Millet, Martha U. Gillette, Jianming Liu, Marni D. Boppart, Gabriel Popescu

Research output: Contribution to journal › Review article › peer-review

Abstract

Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

Original language	English (US)
Pages (from-to)	2501-2511
Number of pages	11
Journal	Journal of Computational and Theoretical Nanoscience
Volume	7
Issue number	12
DOIs	https://doi.org/10.1166/jctn.2010.1637
State	Published - Dec 2010

Keywords

Cells
Fourier transform light scattering
Phase
Quantitative phase microscopy
Scattering
Tissue

ASJC Scopus subject areas

Condensed Matter Physics
Electrical and Electronic Engineering
General Materials Science
Computational Mathematics
General Chemistry

Online availability

10.1166/jctn.2010.1637

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AU - Ding, Huafeng

AU - Wang, Zhuo

AU - Nguyen, Freddy T.

AU - Boppart, Stephen A.

AU - Millet, Larry J.

AU - Gillette, Martha U.

AU - Liu, Jianming

AU - Boppart, Marni D.

AU - Popescu, Gabriel

PY - 2010/12

Y1 - 2010/12

N2 - Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

AB - Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

KW - Cells

KW - Fourier transform light scattering

KW - Phase

KW - Quantitative phase microscopy

KW - Scattering

KW - Tissue

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Fourier transform light scattering (FTLS) of cells and tissues

Abstract

Keywords

ASJC Scopus subject areas

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