Fourier transform infrared vibrational spectroscopic imaging: Integrating microscopy and molecular recognition

Ira W. Levin, Rohit Bhargava

Research output: Contribution to journalArticlepeer-review

Abstract

The recent development of Fourier transform infrared (FTIR) spectroscopic imaging has enhanced our capability to examine, on a microscopic scale, the spatial distribution of vibrational spectroscopic signatures of materials spanning the physical and biomedical disciplines. Recent activity in this emerging area has concentrated on instrumentation development, theoretical analyses to provide guidelines for imaging practice, novel data processing algorithms, and the introduction of the technique to new fields. To illustrate the impact and promise of this spectroscopic imaging methodology, we present fundamental principles of the technique in the context of FTIR spectroscopy and review new applications in various venues ranging from the physical chemistry of macromolecular systems to the detection of human disease.

Original languageEnglish (US)
Pages (from-to)429-474
Number of pages46
JournalAnnual Review of Physical Chemistry
Volume56
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Bone tissue
  • Brain tissue
  • Breast tissue
  • Drug delivery
  • Esophageal tissue
  • Fourier transform infrared spectroscopy
  • Histopathology
  • Interferometry
  • Pharmaceuticals
  • Prostate tissue
  • Single cells
  • Skin tissue

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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