Fourier transform-infrared spectroscopic imaging: The emerging evolution from a microscopy tool to a cancer imaging modality

Gokulakrishnan Srinivasan, Rohit Bhargava

Research output: Contribution to journalArticlepeer-review

Abstract

The integration of Fourier transform-infrared (FT-IR) spectroscopy with microscopy facilitates analysis of spatially resolved spectral information, allowing the examination of the structure, chemical composition and building of two-dimensional maps of a heterogeneous materials. Time-resolved FT-IR imaging provide spatially resolved, millisecond-level dynamics over large sample areas, evaluating various functional groups at different pixels. FT-IR spectrometric imaging instrumentation include detectors and various modes of data collection (time-resolved imaging), for sampling. High-quality FT-IR spectrometric imaging is used for analyzing cervical cancer such as squamous cell carcinoma and adenocarcinoma using computer analysis of spectra.

Original languageEnglish (US)
Pages (from-to)30-43
Number of pages14
JournalSpectroscopy (Santa Monica)
Volume22
Issue number7
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Spectroscopy

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