Fourier transform infrared (Ft-Ir) spectroscopic imaging for solid tumor histopathology

Sreeradha Biswas, Michael J. Walsh, Rohit Bhargava

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fourier transform infrared (FT-IR) spectroscopic imaging has shown great promise in becoming a powerful tool in cytology and histopathology. Applications for cancer diagnoses in solid tumors are especially attractive as samples are spatially complex and involve myriad molecular changes whereas there are many shortcomings in current clinical practice that can be addressed. Here we review the current state of the art in applying FT-IR imaging for analyzing solid tumors. We focus on instrumentation that is relatively new, emerging fundamental understanding gained by new theoretical advances, data analysis and selected, illustrative applications in cancer histopathology.

Original languageEnglish (US)
Title of host publicationOptical Spectroscopy and Computational Methods in Biology and Medicine
PublisherSpringer Netherlands
Pages475-504
Number of pages30
ISBN (Electronic)9789400778320
ISBN (Print)9789400778313
DOIs
StatePublished - Jan 1 2014

Keywords

  • Bayesian classification
  • Breast
  • Cancer pathology
  • Discrete frequency
  • Fourier transform infrared imaging
  • Histopathology
  • Instrumentation
  • Lasers
  • Metrics
  • Prostate
  • Statistical pattern recognition
  • Theory
  • Tissue imaging

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Biswas, S., Walsh, M. J., & Bhargava, R. (2014). Fourier transform infrared (Ft-Ir) spectroscopic imaging for solid tumor histopathology. In Optical Spectroscopy and Computational Methods in Biology and Medicine (pp. 475-504). Springer Netherlands. https://doi.org/10.1007/978-94-007-7832-0_16