Four-scale description of membrane sculpting by BAR domains

Anton Arkhipov, Ying Yin, Klaus Schulten

Research output: Contribution to journalArticle

Abstract

BAR domains are proteins that sense and sculpt curved membranes in cells, furnishing a relatively well-studied example of mechanisms employed in cellular morphogenesis. We report a computational study of membrane bending by BAR domains at four levels of resolution, described by 1), all-atom molecular dynamics; 2), residue-based coarse-graining (resolving single amino acids and lipid molecules); 3), shape-based coarse-graining (resolving overall protein and membrane shapes); and 4), a continuum elastic membrane model. Membrane sculpting performed by BAR domains collectively is observed in agreement with experiments. Different arrangements of BAR domains on the membrane surface are found to lead to distinct membrane curvatures and bending dynamics.

Original languageEnglish (US)
Pages (from-to)2806-2821
Number of pages16
JournalBiophysical journal
Volume95
Issue number6
DOIs
StatePublished - Sep 15 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics

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