Four-dimensional MR cardiovascular imaging: Method and applications

Anthony G. Christodoulou, Bo Zhao, Haosen Zhang, Chien Ho, Zhi-Pei Liang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magnetic resonance imaging (MRI) has long been recognized as a powerful tool for cardiovascular imaging because of its unique potential to measure blood flow, cardiac wall motion and tissue properties jointly. However, many clinical applications of cardiac MRI have been limited by low imaging speed. Three-dimensional cardiovascular MRI in real-time, or 4D cardiovascular MRI without cardiac and respiratory gating or triggering, remains an important technological goal of the MR cardiovascular research community. In this paper, we present a novel technique to achieve 4D cardiovascular MR imaging in unprecedented spatiotemporal resolution. This breakthrough is made possible through a creative use of sparse sampling theory and parallel imaging with phased array coils and a novel implementation of data acquisition and image reconstruction. We have successfully used the technique to perform 4D cardiovascular imaging on rats, achieving 0.65 mm × 0.65 mm × 0.31 mm spatial resolution with a frame rate of 67 fps. This capability enables simultaneous imaging of cardiac motion, respiratory motion, and first-pass myocardial perfusion. This in turn allows multiple cardiac assessments including measurement of ejection fraction, cardiac output, and myocardial blood flow in a single experiment. We believe that the proposed technique can open up many important applications of cardiovascular imaging and have significant impact on the field.

Original languageEnglish (US)
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages3732-3735
Number of pages4
DOIs
StatePublished - Dec 26 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: Aug 30 2011Sep 3 2011

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period8/30/119/3/11

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Christodoulou, A. G., Zhao, B., Zhang, H., Ho, C., & Liang, Z-P. (2011). Four-dimensional MR cardiovascular imaging: Method and applications. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 3732-3735). [6090635] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090635