How application of force affects actin remodelling during mechanotransduction has remained unclear. Mechanical manipulation of the cell cortex is now shown to trigger actin monomer release from filaments, which in turn activates formin-dependent actin filament elongation. This force-sensitive actin polymerization does not require GTPases or membrane receptors, but it involves actin itself.

Original languageEnglish (US)
Pages (from-to)345-346
Number of pages2
JournalNature Cell Biology
Issue number4
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Cell Biology

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