Formation and characterization of polyglutamate core-shell microspheres

Elizabeth M. Dibbern, Farah Jean Jacques Toublan, Kenneth S. Suslick

Research output: Contribution to journalArticlepeer-review

Abstract

The need for organ-targeted delivery of drugs and imaging agents creates an interest in biocompatible, biodegradable vesicles. We make protein microspheres using high-intensity ultrasound; these microspheres have a protein shell and a hydrophobic interior, making them ideal for delivering hydrophobic materials. We have previously shown that various proteins, e.g., bovine serum albumin (BSA), form a microsphere shell stabilized by interprotein cross-linking of cysteine residues. In this study, polyglutamate was used to form core-shell microspheres at slightly basic pH using sonication. These particles are smaller than our previous protein microspheres and are stable under conditions encountered in vivo. The stability of polyglutamate microspheres appears to be due to hydrogen bonding networks and not covalent cross-linking.

Original languageEnglish (US)
Pages (from-to)6540-6541
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number20
DOIs
StatePublished - May 24 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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