TY - JOUR
T1 - Forces in stem cells and cancer stem cells
AU - Chowdhury, Farhan
AU - Huang, Bo
AU - Wang, Ning
N1 - We regret that due to space limitations many other studies are not cited. We acknowledge the support of NIH grants GM072744 (N.W.) and R15GM148440 (F.C.) and Natural Science Foundation of China ( 81788101 to B.H.). N.W. acknowledges Hoeft Professorship of University of Illinois at Urbana-Champaign.
We regret that due to space limitations many other studies are not cited. We acknowledge the support of NIH grants GM072744 (N.W.) and R15GM148440 (F.C.) and Natural Science Foundation of China (81788101 to B.H.). N.W. acknowledges Hoeft Professorship of University of Illinois at Urbana-Champaign.
PY - 2022/6
Y1 - 2022/6
N2 - Endogenous and exogenous forces are critical in physiology and pathology of the human body. Increasing evidence suggests that these forces, mechanics, and force-associated signaling are essential in regulating functions of living cells. Here we review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem cells, adult stem cells, and cancer stem cells and the pathways of mechanotransduction in cells. Stem-cells based models are useful in understanding how forces influence physiology, pathology, and embryonic development, which is incompletely understood, especially for mammals. We highlight increasing efforts and emerging favorable clinical outcomes in mechanomedicine, application of mechanobiology to medicine. Major progresses in mechanobiology, the pillar of mechanomedicine and mechanohealth (application of mechanobiology to health), are pivotal in understanding the life of force and making substantial advances in medicine and health.
AB - Endogenous and exogenous forces are critical in physiology and pathology of the human body. Increasing evidence suggests that these forces, mechanics, and force-associated signaling are essential in regulating functions of living cells. Here we review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem cells, adult stem cells, and cancer stem cells and the pathways of mechanotransduction in cells. Stem-cells based models are useful in understanding how forces influence physiology, pathology, and embryonic development, which is incompletely understood, especially for mammals. We highlight increasing efforts and emerging favorable clinical outcomes in mechanomedicine, application of mechanobiology to medicine. Major progresses in mechanobiology, the pillar of mechanomedicine and mechanohealth (application of mechanobiology to health), are pivotal in understanding the life of force and making substantial advances in medicine and health.
KW - Adult stem cells
KW - Embryogenesis
KW - Force
KW - Gastrulation
KW - Pluripotent stem cells
UR - http://www.scopus.com/inward/record.url?scp=85127793390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85127793390&partnerID=8YFLogxK
U2 - 10.1016/j.cdev.2022.203776
DO - 10.1016/j.cdev.2022.203776
M3 - Review article
C2 - 35346899
AN - SCOPUS:85127793390
SN - 2667-2901
VL - 170
JO - Cells and Development
JF - Cells and Development
M1 - 203776
ER -