TY - JOUR
T1 - Force as a probe of membrane protein structure and function
AU - Leckband, D.
PY - 2001/8/1
Y1 - 2001/8/1
N2 - Force measurement techniques are being used increasingly to explore the mechanical properties of proteins, as well as the structural origins of intermolecular forces. Developments in instrumentation and the increasing availability of engineered and purified membrane proteins have widely expanded the range of biological systems that can be addressed. Within the past year, force measurements have identified novel mechanisms of binding between cell-surface proteins, as well as the mechanical properties of integral membrane proteins and the intramolecular interactions that stabilize their structures.
AB - Force measurement techniques are being used increasingly to explore the mechanical properties of proteins, as well as the structural origins of intermolecular forces. Developments in instrumentation and the increasing availability of engineered and purified membrane proteins have widely expanded the range of biological systems that can be addressed. Within the past year, force measurements have identified novel mechanisms of binding between cell-surface proteins, as well as the mechanical properties of integral membrane proteins and the intramolecular interactions that stabilize their structures.
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U2 - 10.1016/S0959-440X(00)00229-3
DO - 10.1016/S0959-440X(00)00229-3
M3 - Review article
C2 - 11495735
AN - SCOPUS:0035423783
SN - 0959-440X
VL - 11
SP - 433
EP - 439
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 4
ER -