Force as a probe of membrane protein structure and function

Research output: Contribution to journalReview articlepeer-review


Force measurement techniques are being used increasingly to explore the mechanical properties of proteins, as well as the structural origins of intermolecular forces. Developments in instrumentation and the increasing availability of engineered and purified membrane proteins have widely expanded the range of biological systems that can be addressed. Within the past year, force measurements have identified novel mechanisms of binding between cell-surface proteins, as well as the mechanical properties of integral membrane proteins and the intramolecular interactions that stabilize their structures.

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 1 2001

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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