Foods as production and delivery vehicles for human vaccines

Schuyler S. Korban, Sergei F. Krasnyanski, Dennis E. Buetow

Research output: Contribution to journalArticlepeer-review


Vaccination is a great asset for eradication of infectious diseases in humans and animals. With the prevalence of antibiotic resistant bacterial strains and an alarming increase in new and re-emerging pathogens, the need for vaccination continues to be a high priority for mammalian diseases. In the last several years, a novel approach for developing improved mucosal subunit vaccines has emerged by exploiting the use of genetically modified plants. It has been demonstrated that plant-derived antigens are functionally similar to conventional vaccines and can induce neutralizing antibodies in mammalian hosts. Using genetically engineered plants for the production of immunogenic peptides also provides a new approach for the delivery of a plant-based subunit vaccine, i.e., oral delivery, provided these immunogenic peptides are expressed in an edible part of the plant, such as grain or fruit. Thus, food crops can play a significant new role in promoting human health by serving as vehicles for both production and delivery of vaccines.

Original languageEnglish (US)
Pages (from-to)212S-217S
JournalJournal of the American College of Nutrition
StatePublished - Jun 1 2002


  • Food crops
  • Oral edible vaccines
  • Plant-based vaccines
  • Transgenic plants

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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