Fomite-mediated transmission as a sufficient pathway: A comparative analysis across three viral pathogens 11 Medical and Health Sciences 1117 Public Health and Health Services

Alicia N.M. Kraay, Michael A.L. Hayashi, Nancy Hernandez-Ceron, Ian H. Spicknall, Marisa C. Eisenberg, Rafael Meza, Joseph N.S. Eisenberg

Research output: Contribution to journalArticlepeer-review


Background: Fomite mediated transmission can be an important pathway causing significant disease transmission in number of settings such as schools, daycare centers, and long-term care facilities. The importance of these pathways relative to other transmission pathways such as direct person-person or airborne will depend on the characteristics of the particular pathogen and the venue in which transmission occurs. Here we analyze fomite mediated transmission through a comparative analysis across multiple pathogens and venues. Methods: We developed and analyzed a compartmental model that explicitly accounts for fomite transmission by including pathogen transfer between hands and surfaces. We consider two sub-types of fomite-mediated transmission: direct fomite (e.g., shedding onto fomites) and hand-fomite (e.g., shedding onto hands and then contacting fomites). We use this model to examine three pathogens with distinct environmental characteristics (influenza, rhinovirus, and norovirus) in four venue types. To parameterize the model for each pathogen we conducted a thorough literature search. Results: Based on parameter estimates from the literature the reproductive number (R0) for the fomite route for rhinovirus and norovirus is greater than 1 in nearly all venues considered, suggesting that this route can sustain transmission. For influenza, on the other hand, R 0 for the fomite route is smaller suggesting many conditions in which the pathway may not sustain transmission. Additionally, the direct fomite route is more relevant than the hand-fomite route for influenza and rhinovirus, compared to norovirus. The relative importance of the hand-fomite vs. direct fomite route for norovirus is strongly dependent on the fraction of pathogens initially shed to hands. Sensitivity analysis stresses the need for accurate measurements of environmental inactivation rates, transfer efficiencies, and pathogen shedding. Conclusions: Fomite-mediated transmission is an important pathway for the three pathogens examined. The effectiveness of environmental interventions differs significantly both by pathogen and venue. While fomite-based interventions may be able to lower R0 for fomites below 1 and interrupt transmission, rhinovirus and norovirus are so infectious (R 0 > > 1 R0>>1) that single environmental interventions are unlikely to interrupt fomite transmission for these pathogens.

Original languageEnglish (US)
Article number540
JournalBMC Infectious Diseases
Issue number1
StatePublished - Oct 29 2018
Externally publishedYes


  • Environmental Infection Transmission System (EITS)
  • Fomite mediated transmission
  • Mathematical model
  • SIR epidemic model

ASJC Scopus subject areas

  • Infectious Diseases


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