Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands

Aya Tanatani, Thomas S. Hughes, Jeffrey S. Moore

Research output: Contribution to journalArticlepeer-review

Abstract

A dynamic binding mechanism allows the association of dumbbell-shaped ligand 2 with helical folded oligo(m-phenyleneethynylene)s 1 (see schematic representation). Association constants are oligomer length specific, with a maximum value for the icosamer and docosamer. These oligomers have helical conformations that are highly shape-complementary to 1; shorter and longer oligomers exhibit association constants roughly an order of magnitude smaller.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number2
DOIs
StatePublished - Jan 18 2002

Keywords

  • Chirality
  • Foldamers
  • Host-guest systems
  • Molecular recognition
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands'. Together they form a unique fingerprint.

Cite this