Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands

Aya Tanatani; Thomas S. Hughes; Jeffrey S. Moore

doi:10.1002/1521-3773(20020118)41

Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands

Aya Tanatani, Thomas S. Hughes, Jeffrey S. Moore

Research output: Contribution to journal › Article › peer-review

Abstract

A dynamic binding mechanism allows the association of dumbbell-shaped ligand 2 with helical folded oligo(m-phenyleneethynylene)s 1 (see schematic representation). Association constants are oligomer length specific, with a maximum value for the icosamer and docosamer. These oligomers have helical conformations that are highly shape-complementary to 1; shorter and longer oligomers exhibit association constants roughly an order of magnitude smaller.

Original language	English (US)
Pages (from-to)	325-328
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	2
DOIs	https://doi.org/10.1002/1521-3773(20020118)41
State	Published - Jan 18 2002

Keywords

Chirality
Foldamers
Host-guest systems
Molecular recognition
Self-assembly

ASJC Scopus subject areas

Chemistry(all)

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10.1002/1521-3773(20020118)41

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KW - Self-assembly

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Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands

Abstract

Keywords

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