fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents

Matthew R.G. Brown, James R.A. Benoit, Michal Juhás, Ericson Dametto, Tiffanie T. Tse, Marnie Mac Kay, Bhaskar Sen, Alan M. Carroll, Oleksandr Hodlevskyy, Peter H. Silverstone, Florin Dolcos, Serdar M. Dursun, Andrew J. Greenshaw

Research output: Contribution to journalArticle

Abstract

High-risk behavior in adolescents is associated with injury, mental health problems, and poor outcomes in later life. Improved understanding of the neurobiology of high-risk behavior and impulsivity shows promise for informing clinical treatment and prevention as well as policy to better address high-risk behavior. We recruited 21 adolescents (age 14–17) with a wide range of high-risk behavior tendencies, including medically high-risk participants recruited from psychiatric clinics. Risk tendencies were assessed using the Adolescent Risk Behavior Screen (ARBS). ARBS risk scores correlated highly (0.78) with impulsivity scores from the Barratt Impulsivity scale (BIS). Participants underwent 4.7 Tesla functional magnetic resonance imaging (fMRI) while performing an emotional Go/NoGo task. This task presented an aversive or neutral distractor image simultaneously with each Go or NoGo stimulus. Risk behavior and impulsivity tendencies exhibited similar but not identical associations with fMRI activation patterns in prefrontal brain regions. We interpret these results as reflecting differences in response inhibition, emotional stimulus processing, and emotion regulation in relation to participant risk behavior tendencies and impulsivity levels. The results are consistent with high impulsivity playing an important role in determining high risk tendencies in this sample containing clinically high-risk adolescents.

Original languageEnglish (US)
Article number124
JournalFrontiers in Systems Neuroscience
Volume9
Issue numberSeptember
DOIs
StatePublished - Sep 29 2015

Fingerprint

Impulsive Behavior
Risk-Taking
Emotions
Magnetic Resonance Imaging
Adolescent Behavior
Neurobiology
Inhibition (Psychology)
Psychiatry
Mental Health
Wounds and Injuries
Brain

Keywords

  • ARBS
  • Adolescent
  • Emotional Go/NoGo
  • High-risk behavior
  • Impulsivity
  • Response inhibition

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Brown, M. R. G., Benoit, J. R. A., Juhás, M., Dametto, E., Tse, T. T., Mac Kay, M., ... Greenshaw, A. J. (2015). fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents. Frontiers in Systems Neuroscience, 9(September), [124]. https://doi.org/10.3389/fnsys.2015.00124

fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents. / Brown, Matthew R.G.; Benoit, James R.A.; Juhás, Michal; Dametto, Ericson; Tse, Tiffanie T.; Mac Kay, Marnie; Sen, Bhaskar; Carroll, Alan M.; Hodlevskyy, Oleksandr; Silverstone, Peter H.; Dolcos, Florin; Dursun, Serdar M.; Greenshaw, Andrew J.

In: Frontiers in Systems Neuroscience, Vol. 9, No. September, 124, 29.09.2015.

Research output: Contribution to journalArticle

Brown, MRG, Benoit, JRA, Juhás, M, Dametto, E, Tse, TT, Mac Kay, M, Sen, B, Carroll, AM, Hodlevskyy, O, Silverstone, PH, Dolcos, F, Dursun, SM & Greenshaw, AJ 2015, 'fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents', Frontiers in Systems Neuroscience, vol. 9, no. September, 124. https://doi.org/10.3389/fnsys.2015.00124
Brown, Matthew R.G. ; Benoit, James R.A. ; Juhás, Michal ; Dametto, Ericson ; Tse, Tiffanie T. ; Mac Kay, Marnie ; Sen, Bhaskar ; Carroll, Alan M. ; Hodlevskyy, Oleksandr ; Silverstone, Peter H. ; Dolcos, Florin ; Dursun, Serdar M. ; Greenshaw, Andrew J. / fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents. In: Frontiers in Systems Neuroscience. 2015 ; Vol. 9, No. September.
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