Fluctuation-driven molecular transport through an asymmetric membrane channel

Ioan Kosztin, Klaus Schulten

Research output: Contribution to journalArticle

Abstract

The channel asymmetry of glycerol uptake facilitator (GlpF) was studied using ratchetlike mechanism. The effect of nonequilibrium fluctuations of the cell membrane on the glycerol transport through GlpF was also investigated. Glycerol transport through GlpF can be modeled in terms of overdamped Brownian motion along the axis of the channel as a result of the concentration gradient established at the ends of the channel. The results show that a previously determined asymmetric glycerol potential leads to enhanced inward transport of glycerol.

Original languageEnglish (US)
Article number238102
JournalPhysical review letters
Volume93
Issue number23
DOIs
StatePublished - Dec 3 2004

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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