The channel asymmetry of glycerol uptake facilitator (GlpF) was studied using ratchetlike mechanism. The effect of nonequilibrium fluctuations of the cell membrane on the glycerol transport through GlpF was also investigated. Glycerol transport through GlpF can be modeled in terms of overdamped Brownian motion along the axis of the channel as a result of the concentration gradient established at the ends of the channel. The results show that a previously determined asymmetric glycerol potential leads to enhanced inward transport of glycerol.
ASJC Scopus subject areas
- Physics and Astronomy(all)