Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters

Nicholas Clay; Kwanghyun Baek; Artem Shkumatov; Mei Hsiu Lai; Cartney E. Smith; Max Rich; Hyunjoon Kong

doi:10.1021/am4030998

Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters

Nicholas Clay, Kwanghyun Baek, Artem Shkumatov, Mei Hsiu Lai, Cartney E. Smith, Max Rich, Hyunjoon Kong

Research output: Contribution to journal › Article › peer-review

Abstract

This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

Original language	English (US)
Pages (from-to)	10266-10273
Number of pages	8
Journal	ACS Applied Materials and Interfaces
Volume	5
Issue number	20
DOIs	https://doi.org/10.1021/am4030998
State	Published - Oct 23 2013

Keywords

cell tracking
iron oxide nanoparticles
mechanotransduction
MR imaging
receptor-mediated endocytosis

ASJC Scopus subject areas

General Materials Science
General Medicine

Online availability

10.1021/am4030998

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AU - Smith, Cartney E.

AU - Rich, Max

AU - Kong, Hyunjoon

PY - 2013/10/23

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AB - This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

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KW - mechanotransduction

KW - MR imaging

KW - receptor-mediated endocytosis

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Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters

Abstract

Keywords

ASJC Scopus subject areas

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