Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters

Nicholas Clay, Kwanghyun Baek, Artem Shkumatov, Mei Hsiu Lai, Cartney E. Smith, Max Rich, Hyunjoon Kong

Research output: Contribution to journalArticlepeer-review

Abstract

This study presents a strategy to enhance the uptake of superparamagnetic iron oxide nanoparticle (SPIO) clusters by manipulating the cellular mechanical environment. Specifically, stem cells exposed to an orbital flow ingested almost a 2-fold greater amount of SPIO clusters than those cultured statically. Improvements in magnetic resonance (MR) contrast were subsequently achieved for labeled cells in collagen gels and a mouse model. Overall, this strategy will serve to improve the efficiency of cell tracking and therapies.

Original languageEnglish (US)
Pages (from-to)10266-10273
Number of pages8
JournalACS Applied Materials and Interfaces
Volume5
Issue number20
DOIs
StatePublished - Oct 23 2013

Keywords

  • cell tracking
  • iron oxide nanoparticles
  • mechanotransduction
  • MR imaging
  • receptor-mediated endocytosis

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

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