Flexible tetracycline synthesis yields promising antibiotics

Research output: Contribution to journalShort surveypeer-review


Access to new analogs of the tetracycline family of antibiotics has thus far been limited to compounds that can be prepared by modification of the isolable natural products. An efficient total-synthesis pathway with extraordinary flexibility has now made it possible to identify new tetracycline derivatives with activity against a wide range of antibiotic-resistant bacteria.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
JournalNature chemical biology
Issue number2
StatePublished - Feb 6 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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