Access to new analogs of the tetracycline family of antibiotics has thus far been limited to compounds that can be prepared by modification of the isolable natural products. An efficient total-synthesis pathway with extraordinary flexibility has now made it possible to identify new tetracycline derivatives with activity against a wide range of antibiotic-resistant bacteria.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nature chemical biology|
|State||Published - Feb 6 2009|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology