Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

Jonathan Viventi, Dae Hyeong Kim, Leif Vigeland, Eric S. Frechette, Justin A. Blanco, Yun Soung Kim, Andrew E. Avrin, Vineet R. Tiruvadi, Suk Won Hwang, Ann C. Vanleer, Drausin F. Wulsin, Kathryn Davis, Casey E. Gelber, Larry Palmer, Jan Van Der Spiegel, Jian Wu, Jianliang Xiao, Yonggang Huang, Diego Contreras, John A. RogersBrian Litt

Research output: Contribution to journalArticlepeer-review


Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.

Original languageEnglish (US)
Pages (from-to)1599-1605
Number of pages7
JournalNature Neuroscience
Issue number12
StatePublished - Dec 2011
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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