TY - JOUR
T1 - First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits.
AU - de Camargo, Gregório Miguel Ferreira
AU - Cardoso, Diercles Francisco
AU - Gil, Fernanda Maria Monsalves
AU - Fonseca, Patrícia Dias da Silva
AU - Zetouni, Larissa
AU - Braz, Camila Urbano
AU - de Freitas, Ana Claudia
AU - de Souza, Fábio Ricardo Pablos
AU - Aspilcueta-Borquis, Rusbel Raul
AU - Baldi, Fernando
AU - de Albuquerque, Lucia Galvão
AU - Regitano, Luciana Correia de Almeida
AU - Tonhati, Humberto
N1 - Funding Information:
The authors wish to thank the Fundação de Apoio à Pesquisa do Estado de São Paulo (Fapesp) for the grant of the first author.
PY - 2012/12
Y1 - 2012/12
N2 - Protein JY-1 is a bovine oocyte-specific protein that regulates granulosa cell function and is involved in early embryonic development, influencing the chance of pregnancy. This study investigated molecular markers for the JY-1 gene. Seven SNPs were identified in exon 3 of the gene. The positions of the SNPs in the exon and the respective substitutions are: 163 (T/C), 281 (T/C), 321 (T/C), 532 (T/C), 652 (A/G), 679 (T/C), and 722 (G/C) (GenBank: JN592587 and JF262042.2). SNP 163 is located in a coding region and causes a proline-to-leucine substitution. The other SNPs are located in the 3'UTR region. SNPs 163, 281, 321, and 679 were genotyped in 297 Nellore heifers and the haplotypes were constructed. The haplotypes of JY-1 were not correlated with the traits studied at 5 %.
AB - Protein JY-1 is a bovine oocyte-specific protein that regulates granulosa cell function and is involved in early embryonic development, influencing the chance of pregnancy. This study investigated molecular markers for the JY-1 gene. Seven SNPs were identified in exon 3 of the gene. The positions of the SNPs in the exon and the respective substitutions are: 163 (T/C), 281 (T/C), 321 (T/C), 532 (T/C), 652 (A/G), 679 (T/C), and 722 (G/C) (GenBank: JN592587 and JF262042.2). SNP 163 is located in a coding region and causes a proline-to-leucine substitution. The other SNPs are located in the 3'UTR region. SNPs 163, 281, 321, and 679 were genotyped in 297 Nellore heifers and the haplotypes were constructed. The haplotypes of JY-1 were not correlated with the traits studied at 5 %.
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U2 - 10.1007/s11033-012-1884-5
DO - 10.1007/s11033-012-1884-5
M3 - Article
C2 - 22956026
AN - SCOPUS:85027927631
SN - 0301-4851
VL - 39
SP - 10105
EP - 10109
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 12
ER -