Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters

Denise L. Smith, Nicholas M.G. Friedman, Samuel I. Bloom, William L. Armero, Brandt D. Pence, Marc D. Cook, Bo Fernhall, Gavin P. Horn, Jeff Woods

Research output: Contribution to journalArticle

Abstract

Objective:Sudden cardiac events account for 40% to 50% of firefighter line-of-duty deaths. Inflammatory proteins are strong biomarkers of cardiovascular inflammation. The present study investigated the effects of aspirin supplementation on inflammatory biomarkers following firefighting.Methods:Using a randomized, placebo-controlled, double-blind crossover design, 24 male firefighters (48.2 ± 5.9 years) were allocated into four conditions: acute (81 mg; single-dose) aspirin and placebo supplementation, and chronic (81 mg; 14 days) aspirin and placebo supplementation. Inflammatory proteins [interleukin (IL)-6, C-reactive protein (CRP), intracellular adhesion molecule (ICAM)-1, P-selectin, matrix metalloproteinase-9 (MMP-9)] and antioxidant potential [total antioxidant capacity (TAC)] were measured pre- and post-structural firefighting drills.Results:Firefighting activities significantly increased IL-6, MMP-9, and P-Selectin; however, no changes in TAC and ICAM-1 were detected. Neither acute nor chronic aspirin supplementation attenuated this inflammatory response.Conclusion:Firefighting significantly increases inflammatory biomarkers and neither acute nor chronic low-dose aspirin mitigates this response.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalJournal of occupational and environmental medicine
Volume61
Issue number7
DOIs
StatePublished - Jul 1 2019

Keywords

  • anti-inflammatory
  • cardiovascular events
  • cytokines
  • fire fighter
  • inflammation
  • oxidative stress
  • pro-inflammatory

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Smith, D. L., Friedman, N. M. G., Bloom, S. I., Armero, W. L., Pence, B. D., Cook, M. D., Fernhall, B., Horn, G. P., & Woods, J. (2019). Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters. Journal of occupational and environmental medicine, 61(7), 617-622. https://doi.org/10.1097/JOM.0000000000001626