Feeding tomato and broccoli powders enriched with bioactives improves bioactivity markers in rats

Ann G. Liu, Sonja E. Volker, Elizabeth H Jeffery, John W Erdman

Research output: Contribution to journalArticlepeer-review

Abstract

Many studies have evaluated the cancer -preventive potential of individual bioactives from tomatoes and broccoli, but few have examined them within the context of a whole food. Male Copenhagen rats were fed diets containing 10% standard tomato powder, tomato enriched with lycopene or total carotenoids, standard broccoli floret, broccoli sprouts, or broccoli enriched with indole glucosinolates or selenium for 7 days. All broccoli diets increased the activity of colon quinone reductase (NQO1). Indole glucosinolate-enriched broccoli and selenium-enriched broccoli increased hepatic NQO1 and cytochrome P450 1A activity (P < 0.05). Standard broccoli and lycopene-enriched tomato diets down-regulated prostatic glutathione S-transferase P1 mRNA expression. Different tomato diets resulted in altered hepatic accumulation of lycopene, phytofluene, and phytoene. These results demonstrate that the bioactive content of vegetables affects both tissue content of bioactives and activity of detoxification enzymes. Enhancing bioactive content of tomatoes and broccoli may enhance efficacy in the prevention of prostate cancer

Original languageEnglish (US)
Pages (from-to)7304-7310
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number16
DOIs
StatePublished - Sep 23 2009

Keywords

  • Broccoli
  • Cancer
  • Detoxification enzymes
  • Indole-3-carbinol
  • Lycopene
  • Selenium
  • Sulforaphane
  • Tomato

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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