Feasibility study design and methods for a home-based, square-stepping exercise program among older adults with multiple sclerosis: The SSE-MS project

Emerson Sebastião, Edward McAuley, Ryosuke Shigematsu, Robert W. Motl

Research output: Contribution to journalArticle


We propose a randomized controlled trial (RCT) examining the feasibility of square-stepping exercise (SSE) delivered as a home-based program for older adults with multiple sclerosis (MS). We will assess feasibility in the four domains of process, resources, management and scientific outcomes. The trial will recruit older adults (aged 60 years and older) with mild-to-moderate MS-related disability who will be randomized into intervention or attention control conditions. Participants will complete assessments before and after completion of the conditions delivered over a 12-week period. Participants in the intervention group will have biweekly meetings with an exercise trainer in the Exercise Neuroscience Research Laboratory and receive verbal and visual instruction on step patterns for the SSE program. Participants will receive a mat for home-based practice of the step patterns, an instruction manual, and a logbook and pedometer for monitoring compliance. Compliance will be further monitored through weekly scheduled Skype calls. This feasibility study will inform future phase II and III RCTs that determine the actual efficacy and effectiveness of a home-based exercise program for older adults with MS.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalContemporary Clinical Trials Communications
StatePublished - Sep 2017



  • Exercise
  • Feasibility
  • Home-based
  • Multiple sclerosis
  • Older adults

ASJC Scopus subject areas

  • Pharmacology

Cite this