Abstract
Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.
| Original language | English (US) |
|---|---|
| Article number | 6342 |
| Journal | Nature communications |
| Volume | 6 |
| DOIs | |
| State | Published - Apr 28 2015 |
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ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
Cite this
Fat, fibre and cancer risk in African Americans and rural Africans. / O'Keefe, Stephen J.D.; Li, Jia V.; Lahti, Leo; Ou, Junhai; Carbonero, Franck; Mohammed, Khaled; Posma, Joram M.; Kinross, James; Wahl, Elaine; Ruder, Elizabeth; Vipperla, Kishore; Naidoo, Vasudevan; Mtshali, Lungile; Tims, Sebastian; Puylaert, Philippe G.B.; Delany, James; Krasinskas, Alyssa; Benefiel, Ann C.; Kaseb, Hatem O.; Newton, Keith; Nicholson, Jeremy K.; De Vos, Willem M.; Gaskins, H Rex; Zoetendal, Erwin G.
In: Nature communications, Vol. 6, 6342, 28.04.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fat, fibre and cancer risk in African Americans and rural Africans
AU - O'Keefe, Stephen J.D.
AU - Li, Jia V.
AU - Lahti, Leo
AU - Ou, Junhai
AU - Carbonero, Franck
AU - Mohammed, Khaled
AU - Posma, Joram M.
AU - Kinross, James
AU - Wahl, Elaine
AU - Ruder, Elizabeth
AU - Vipperla, Kishore
AU - Naidoo, Vasudevan
AU - Mtshali, Lungile
AU - Tims, Sebastian
AU - Puylaert, Philippe G.B.
AU - Delany, James
AU - Krasinskas, Alyssa
AU - Benefiel, Ann C.
AU - Kaseb, Hatem O.
AU - Newton, Keith
AU - Nicholson, Jeremy K.
AU - De Vos, Willem M.
AU - Gaskins, H Rex
AU - Zoetendal, Erwin G.
PY - 2015/4/28
Y1 - 2015/4/28
N2 - Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.
AB - Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.
UR - http://www.scopus.com/inward/record.url?scp=84929094853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929094853&partnerID=8YFLogxK
U2 - 10.1038/ncomms7342
DO - 10.1038/ncomms7342
M3 - Article
C2 - 25919227
AN - SCOPUS:84929094853
VL - 6
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 6342
ER -