Fat, fibre and cancer risk in African Americans and rural Africans

Stephen J.D. O'Keefe, Jia V. Li, Leo Lahti, Junhai Ou, Franck Carbonero, Khaled Mohammed, Joram M. Posma, James Kinross, Elaine Wahl, Elizabeth Ruder, Kishore Vipperla, Vasudevan Naidoo, Lungile Mtshali, Sebastian Tims, Philippe G.B. Puylaert, James Delany, Alyssa Krasinskas, Ann C. Benefiel, Hatem O. Kaseb, Keith NewtonJeremy K. Nicholson, Willem M. De Vos, H Rex Gaskins, Erwin G. Zoetendal

Research output: Contribution to journalArticle

Abstract

Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.

Original languageEnglish (US)
Article number6342
JournalNature communications
Volume6
DOIs
StatePublished - Apr 28 2015

Fingerprint

fats
African Americans
diets
Nutrition
cancer
Fats
fibers
Fibers
biomarkers
Tumor Biomarkers
Diet
Bile Acids and Salts
food
Neoplasms
Food
acids
fermentation
Metabolome
Volatile Fatty Acids
Microbiota

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

O'Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., ... Zoetendal, E. G. (2015). Fat, fibre and cancer risk in African Americans and rural Africans. Nature communications, 6, [6342]. https://doi.org/10.1038/ncomms7342

Fat, fibre and cancer risk in African Americans and rural Africans. / O'Keefe, Stephen J.D.; Li, Jia V.; Lahti, Leo; Ou, Junhai; Carbonero, Franck; Mohammed, Khaled; Posma, Joram M.; Kinross, James; Wahl, Elaine; Ruder, Elizabeth; Vipperla, Kishore; Naidoo, Vasudevan; Mtshali, Lungile; Tims, Sebastian; Puylaert, Philippe G.B.; Delany, James; Krasinskas, Alyssa; Benefiel, Ann C.; Kaseb, Hatem O.; Newton, Keith; Nicholson, Jeremy K.; De Vos, Willem M.; Gaskins, H Rex; Zoetendal, Erwin G.

In: Nature communications, Vol. 6, 6342, 28.04.2015.

Research output: Contribution to journalArticle

O'Keefe, SJD, Li, JV, Lahti, L, Ou, J, Carbonero, F, Mohammed, K, Posma, JM, Kinross, J, Wahl, E, Ruder, E, Vipperla, K, Naidoo, V, Mtshali, L, Tims, S, Puylaert, PGB, Delany, J, Krasinskas, A, Benefiel, AC, Kaseb, HO, Newton, K, Nicholson, JK, De Vos, WM, Gaskins, HR & Zoetendal, EG 2015, 'Fat, fibre and cancer risk in African Americans and rural Africans', Nature communications, vol. 6, 6342. https://doi.org/10.1038/ncomms7342
O'Keefe SJD, Li JV, Lahti L, Ou J, Carbonero F, Mohammed K et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nature communications. 2015 Apr 28;6. 6342. https://doi.org/10.1038/ncomms7342
O'Keefe, Stephen J.D. ; Li, Jia V. ; Lahti, Leo ; Ou, Junhai ; Carbonero, Franck ; Mohammed, Khaled ; Posma, Joram M. ; Kinross, James ; Wahl, Elaine ; Ruder, Elizabeth ; Vipperla, Kishore ; Naidoo, Vasudevan ; Mtshali, Lungile ; Tims, Sebastian ; Puylaert, Philippe G.B. ; Delany, James ; Krasinskas, Alyssa ; Benefiel, Ann C. ; Kaseb, Hatem O. ; Newton, Keith ; Nicholson, Jeremy K. ; De Vos, Willem M. ; Gaskins, H Rex ; Zoetendal, Erwin G. / Fat, fibre and cancer risk in African Americans and rural Africans. In: Nature communications. 2015 ; Vol. 6.
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