While technology scaling has presented many new and exciting opportunities, new design challenges have arisen due to increased density, and delay and power variations. High- level synthesis has been touted as a solution to these problems, as it can significantly reduce the number of man hours required for a design by raising the level of abstraction. In this paper, we propose a new variation-aware high-level synthesis binding/module selection algorithm, named FastYield, which takes into consideration multiplexers, functional units, registers, and interconnects. Additionally, FastYield connects with the lower levels of the design hierarchy through its inclusion of a timing driven floorplanner guided by a statistical static timing analysis(SSTA) engine which is used to modify/enhance the synthesis solution. FastYield is able to incorporate spatial correlations of process variations in its optimization, which are shown to affect performance yield. On average, FastYield achieves a clock period that is 14.5% smaller, and a performance yield gain of 78.9%, when compared to a variation-unaware algorithm. By making use of accurate timing information, FastYield's rebind- ing improves performance yield by an average of 9.8% over the initial binding, for the same clock period. To the best of our knowledge, this is the first high-level synthesis binding/module selection algorithm that is layout-driven and variation aware.