TY - JOUR
T1 - Fast and localized event-related optical signals(EROS) in the human occipital cortex
T2 - Comparisons with the visual evoked potential and fMRI
AU - Gratton, Gabriele
AU - Fabiani, Monica
AU - Corballis, Paul M.
AU - Hood, Donald C.
AU - Goodman-Wood, Marsha R.
AU - Hirsch, Joy
AU - Kim, Karl
AU - Friedman, David
AU - Gratton, Enrico
N1 - Funding Information:
This work was supported in part by Grants MH57125 from NIMH to Dr. Gabriele Gratton, EY02115 from the NEI to Dr. Donald Hood, AG05213 from NIA to Dr. David Friedman, CA57032 from NIH to Dr. Enrico Gratton, the Center for Functional Imaging at the MSKCC (Dr. Joy Hirsch, Director), and the William T. Morris Foundation Fellowship to Karl Kim. We thank Victoria Kasmerski, M. Catherine DeSoto, and two anonymous reviewers for comments on an earlier version of the manuscript, and we thank Eunhee Cho for helping with data collection.
PY - 1997/10
Y1 - 1997/10
N2 - Localized evoked activity of the human cortex produces fast changes in optical properties that can be detected noninvasively (event-related optical signal, or EROS). In the present study a fast EROS response (latency ≃ 100 ms) elicited in the occipital cortex by visual stimuli showed spatial congruence with fMRI signals and temporal correspondence with VEPs, thus combining subcentimeter spatial localization with subsecond temporal resolution. fMRI signals were recorded from striate and extrastriate cortex. Both areas showed EROS peaks, but at different latencies after stimulation (100 and 200-300 ms, respectively). These results suggest that EROS manifests localized neuronal activity associated with information processing. The temporal resolution and spatial localization of this signal make it a promising tool for studying the time course of activity in localized brain areas and for bridging the gap between electrical and hemodynamic imaging methods.
AB - Localized evoked activity of the human cortex produces fast changes in optical properties that can be detected noninvasively (event-related optical signal, or EROS). In the present study a fast EROS response (latency ≃ 100 ms) elicited in the occipital cortex by visual stimuli showed spatial congruence with fMRI signals and temporal correspondence with VEPs, thus combining subcentimeter spatial localization with subsecond temporal resolution. fMRI signals were recorded from striate and extrastriate cortex. Both areas showed EROS peaks, but at different latencies after stimulation (100 and 200-300 ms, respectively). These results suggest that EROS manifests localized neuronal activity associated with information processing. The temporal resolution and spatial localization of this signal make it a promising tool for studying the time course of activity in localized brain areas and for bridging the gap between electrical and hemodynamic imaging methods.
KW - Event-related optical signal (EROS)
KW - FMRI
KW - Functional brain mapping
KW - Noninvasive optical imaging
KW - Photon migration in tissues
KW - VEPs
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U2 - 10.1006/nimg.1997.0298
DO - 10.1006/nimg.1997.0298
M3 - Article
C2 - 9344821
AN - SCOPUS:0030690411
SN - 1053-8119
VL - 6
SP - 168
EP - 180
JO - NeuroImage
JF - NeuroImage
IS - 3
ER -