Abstract
Postprandial lipaemia is associated with activation of factor VII (FVII) and efflux of cholesterol from tissues to nascent plasma high density lipoproteins (HDL) containing apolipoprotein A-I (apo A-I). To determine whether FVII activation and cholesterol efflux occur together in other situations, the responses to intravenous infusion of HDL-like apop A-I/phosphatidylcholine discs were measured in 10 healthy men. Disc infusion (40 mg apo A-I/kg body weight) over 4 h was followed by increases in HDL cholesteryl ester and plasma apo A-I (p <0.0001). Significant activation of FVII was apparent during infusion in fasting subjects (p = 0.03), activated FVII averaging 123% of baseline value by 12 h (p <0.0001). Plasma thrombin-antithrombin (TAT) complex increased to 156% of baseline level by 12 h (p >0.05) but individual responses differed considerably. Peak TAT post-infusion was associated inversely with peak HDL triglyceride concentration (p = 0.004). The coagulation responses to disc-infusion may be due to transfer of phosphatidylserine to cell surfaces during cholesterol efflux.
Original language | English (US) |
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Pages (from-to) | 477-482 |
Number of pages | 6 |
Journal | Thrombosis and Haemostasis |
Volume | 87 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Apolipoprotein A-I
- Factor VII
- High density lipoprotein
- Phospholipids
- Reverse cholesterol transport
ASJC Scopus subject areas
- Hematology