Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: Possible relevance for postprandial lipaemia

George J. Miller, C. J. Cooke, M. N. Nanjee, D. J. Howarth, J. A. Cooper, I. P. Stepanova, J. H. Morrissey, N. E. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Postprandial lipaemia is associated with activation of factor VII (FVII) and efflux of cholesterol from tissues to nascent plasma high density lipoproteins (HDL) containing apolipoprotein A-I (apo A-I). To determine whether FVII activation and cholesterol efflux occur together in other situations, the responses to intravenous infusion of HDL-like apop A-I/phosphatidylcholine discs were measured in 10 healthy men. Disc infusion (40 mg apo A-I/kg body weight) over 4 h was followed by increases in HDL cholesteryl ester and plasma apo A-I (p <0.0001). Significant activation of FVII was apparent during infusion in fasting subjects (p = 0.03), activated FVII averaging 123% of baseline value by 12 h (p <0.0001). Plasma thrombin-antithrombin (TAT) complex increased to 156% of baseline level by 12 h (p >0.05) but individual responses differed considerably. Peak TAT post-infusion was associated inversely with peak HDL triglyceride concentration (p = 0.004). The coagulation responses to disc-infusion may be due to transfer of phosphatidylserine to cell surfaces during cholesterol efflux.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalThrombosis and Haemostasis
Volume87
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Apolipoprotein A-I
  • Factor VII
  • High density lipoprotein
  • Phospholipids
  • Reverse cholesterol transport

ASJC Scopus subject areas

  • Hematology

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