Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor

Marvin J. Meyers; Kathryn E. Carlson; John A. Katzenellenbogen

doi:10.1016/S0960-894X(98)00652-0

Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor

Marvin J. Meyers, Kathryn E. Carlson, John A. Katzenellenbogen

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.

Original language	English (US)
Pages (from-to)	3589-3594
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(98)00652-0
State	Published - Dec 15 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00652-0

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title = "Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor",

abstract = "A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.",

author = "Meyers, {Marvin J.} and Carlson, {Kathryn E.} and Katzenellenbogen, {John A.}",

note = "Funding Information: Acknowledgments: We thank Christopher M. Cassidy for preliminary work on the synthesis of these compounds. We are grateful for supporto f this researcht hrougha grant from the National Instituteso f Health (PHS 5R37 DK15556).",

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AU - Meyers, Marvin J.

AU - Carlson, Kathryn E.

AU - Katzenellenbogen, John A.

N1 - Funding Information: Acknowledgments: We thank Christopher M. Cassidy for preliminary work on the synthesis of these compounds. We are grateful for supporto f this researcht hrougha grant from the National Instituteso f Health (PHS 5R37 DK15556).

PY - 1998/12/15

Y1 - 1998/12/15

N2 - A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.

AB - A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.

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Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor

Abstract

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