Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor

Marvin J. Meyers, Kathryn E. Carlson, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review

Abstract

A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.

Original languageEnglish (US)
Pages (from-to)3589-3594
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number24
DOIs
StatePublished - Dec 15 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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