TY - JOUR
T1 - Facile Synthesis of Helical Multiblock Copolypeptides
T2 - Minimal Side Reactions with Accelerated Polymerization of N-Carboxyanhydrides
AU - Wang, Xuefang
AU - Song, Ziyuan
AU - Tan, Zhengzhong
AU - Zhu, Lingyang
AU - Xue, Tianrui
AU - Lv, Shixian
AU - Fu, Zihuan
AU - Zheng, Xuetao
AU - Ren, Jie
AU - Cheng, Jianjun
N1 - Funding Information:
J.C. acknowledges the support of National Science Foundation (CHE-1709820) and partial support of National Institutes of Health (1R01CA207584). X.W., a visiting student from Tongji University, China, acknowledges the support from China Scholarship Council for his studies in Professor Jianjun Cheng’s laboratory at UIUC.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/11/19
Y1 - 2019/11/19
N2 - Multiblock copolypeptides have attracted broad interests because their potential to form ordered structures and possess protein-mimetic functions. Controlled synthesis of multiblock copolypeptides through the sequential addition of N-carboxyanhydrides (NCAs), especially with the block number higher than five, however, is challenging and rarely reported due to competing side reactions during the polymerization process. Herein, we report the unprecedented synthesis of block copolypeptides with up to 20 blocks, enabled by ultrafast polypeptide chain propagation in a water/chloroform emulsion system that outpaces side reactions and ensures high end-group fidelity. Well-defined multiblock copolypeptides with desired block numbers, block lengths, and block sequences, as well as very low dispersity were readily attainable in a few hours. This method paves the way for the fast production of a large number of sequence-regulated multiblock copolypeptide materials, which may exhibit interesting assembly behaviors and biomedical applications.
AB - Multiblock copolypeptides have attracted broad interests because their potential to form ordered structures and possess protein-mimetic functions. Controlled synthesis of multiblock copolypeptides through the sequential addition of N-carboxyanhydrides (NCAs), especially with the block number higher than five, however, is challenging and rarely reported due to competing side reactions during the polymerization process. Herein, we report the unprecedented synthesis of block copolypeptides with up to 20 blocks, enabled by ultrafast polypeptide chain propagation in a water/chloroform emulsion system that outpaces side reactions and ensures high end-group fidelity. Well-defined multiblock copolypeptides with desired block numbers, block lengths, and block sequences, as well as very low dispersity were readily attainable in a few hours. This method paves the way for the fast production of a large number of sequence-regulated multiblock copolypeptide materials, which may exhibit interesting assembly behaviors and biomedical applications.
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U2 - 10.1021/acsmacrolett.9b00784
DO - 10.1021/acsmacrolett.9b00784
M3 - Article
C2 - 32775039
AN - SCOPUS:85074648637
VL - 8
SP - 1517
EP - 1521
JO - ACS Macro Letters
JF - ACS Macro Letters
SN - 2161-1653
IS - 11
ER -