Fabrication and characterization of a biomimetic hydrogel check valve

Qing Yu, Joseph M. Bauer, Jeffrey S. Moore, David J. Beebe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A biomimetic hydrogel valve that combines the characteristics of both active and passive valves is fabricated and characterized. The microscopic valve consists of a pair of photopolymerized hydrogel bi-strips with different pH sensitivities. At physiological pH, the bi-strip undergoes changes in both shape and size to form a valve. The valve mimics anatomic venous valves both functionally and structurally, allowing fluid flow in one direction while restricting flow in the opposite direction. At an applied pressure of 0.71 psi, the forward flow rate was 140 μL/min, compared to a reverse leakage rate of 2.3 (iL/min at the same pressure. The valve not only provides directional control of the flow, but also reversibly activates (swells) or deactivates (shrinks) based on the chemical environment of the local fluid. The sealing capabilities of the hydrogel materials are also explored.

Original languageEnglish (US)
Title of host publication1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
EditorsAndre Dittmar, David Beebe
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages336-339
Number of pages4
ISBN (Electronic)0780366034, 9780780366039
DOIs
StatePublished - Jan 1 2000
Event1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France
Duration: Oct 12 2000Oct 14 2000

Publication series

Name1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

Other

Other1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
CountryFrance
CityLyon
Period10/12/0010/14/00

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Fabrication and characterization of a biomimetic hydrogel check valve'. Together they form a unique fingerprint.

Cite this