@inproceedings{5a5806ca8dfd4467839f3ec434b9e49f,
title = "Fabrication and characterization of a biomimetic hydrogel check valve",
abstract = "A biomimetic hydrogel valve that combines the characteristics of both active and passive valves is fabricated and characterized. The microscopic valve consists of a pair of photopolymerized hydrogel bi-strips with different pH sensitivities. At physiological pH, the bi-strip undergoes changes in both shape and size to form a valve. The valve mimics anatomic venous valves both functionally and structurally, allowing fluid flow in one direction while restricting flow in the opposite direction. At an applied pressure of 0.71 psi, the forward flow rate was 140 μL/min, compared to a reverse leakage rate of 2.3 (iL/min at the same pressure. The valve not only provides directional control of the flow, but also reversibly activates (swells) or deactivates (shrinks) based on the chemical environment of the local fluid. The sealing capabilities of the hydrogel materials are also explored.",
author = "Qing Yu and Bauer, {Joseph M.} and Moore, {Jeffrey S.} and Beebe, {David J.}",
note = "Publisher Copyright: {\textcopyright} 2000 IEEE.; 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 ; Conference date: 12-10-2000 Through 14-10-2000",
year = "2000",
doi = "10.1109/MMB.2000.893800",
language = "English (US)",
series = "1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "336--339",
editor = "Andre Dittmar and David Beebe",
booktitle = "1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings",
address = "United States",
}