Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers

Iulia Darolti, Alison E. Wright, Benjamin A. Sandkam, Jake Morris, Natasha I. Bloch, Marta Farré, Rebecca C. Fuller, Godfrey R. Bourne, Denis M. Larkin, Felix Breden, Judith E. Mank

Research output: Contribution to journalArticlepeer-review

Abstract

Once recombination is halted between the X and Y chromosomes, sex chromosomes begin to differentiate and transition to heteromorphism. While there is a remarkable variation across clades in the degree of sex chromosome divergence, far less is known about the variation in sex chromosome differentiation within clades. Here, we combined whole-genome and transcriptome sequencing data to characterize the structure and conservation of sex chromosome systems across Poeciliidae, the livebearing clade that includes guppies. We found that the Poecilia reticulata XY system is much older than previously thought, being shared not only with its sister species, Poecilia wingei, but also with Poecilia picta, which diverged roughly 20 million years ago. Despite the shared ancestry, we uncovered an extreme heterogeneity across these species in the proportion of the sex chromosome with suppressed recombination, and the degree of Y chromosome decay. The sex chromosomes in P. reticulata and P. wingei are largely homomorphic, with recombination in the former persisting over a substantial fraction. However, the sex chromosomes in P. picta are completely nonrecombining and strikingly heteromorphic. Remarkably, the profound degradation of the ancestral Y chromosome in P. picta is counterbalanced by the evolution of functional chromosome-wide dosage compensation in this species, which has not been previously observed in teleost fish. Our results offer important insight into the initial stages of sex chromosome evolution and dosage compensation.

Original languageEnglish (US)
Pages (from-to)19031-19036
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number38
DOIs
StatePublished - Sep 17 2019

Keywords

  • Dosage compensation
  • Poeciliids
  • Recombination
  • Y degeneration

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Extreme heterogeneity in sex chromosome differentiation and dosage compensation in livebearers'. Together they form a unique fingerprint.

Cite this