Abstract

Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser cavity, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity and large dynamic range. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors. This journal is

Original languageEnglish (US)
Pages (from-to)1247-1256
Number of pages10
JournalLab on a Chip
Volume13
Issue number7
DOIs
StatePublished - Apr 7 2013

Fingerprint

Optics and Photonics
Laser resonators
Biosensing Techniques
Photonic crystals
Biosensors
Lasers
Biomolecules
Optical resonators
Optical gain
Wavelength
Semiconductors
Stimulated emission
Continuous wave lasers
Semiconductor optical amplifiers
Laser modes
Lighting
Transducers
Plastics
Adsorption
Labels

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Ge, C., Lu, M., George, S., Flood, T. A., Wagner, C., Zheng, J., ... Cunningham, B. T. (2013). External cavity laser biosensor. Lab on a Chip, 13(7), 1247-1256. https://doi.org/10.1039/c3lc41330f

External cavity laser biosensor. / Ge, Chun; Lu, Meng; George, Sherine; Flood, Timothy A.; Wagner, Clark; Zheng, Jie; Pokhriyal, Anusha; Eden, J. Gary; Hergenrother, Paul J.; Cunningham, Brian T.

In: Lab on a Chip, Vol. 13, No. 7, 07.04.2013, p. 1247-1256.

Research output: Contribution to journalArticle

Ge, C, Lu, M, George, S, Flood, TA, Wagner, C, Zheng, J, Pokhriyal, A, Eden, JG, Hergenrother, PJ & Cunningham, BT 2013, 'External cavity laser biosensor', Lab on a Chip, vol. 13, no. 7, pp. 1247-1256. https://doi.org/10.1039/c3lc41330f
Ge C, Lu M, George S, Flood TA, Wagner C, Zheng J et al. External cavity laser biosensor. Lab on a Chip. 2013 Apr 7;13(7):1247-1256. https://doi.org/10.1039/c3lc41330f
Ge, Chun ; Lu, Meng ; George, Sherine ; Flood, Timothy A. ; Wagner, Clark ; Zheng, Jie ; Pokhriyal, Anusha ; Eden, J. Gary ; Hergenrother, Paul J. ; Cunningham, Brian T. / External cavity laser biosensor. In: Lab on a Chip. 2013 ; Vol. 13, No. 7. pp. 1247-1256.
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