Abstract
Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser cavity, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity and large dynamic range. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors. This journal is
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1247-1256 |
| Number of pages | 10 |
| Journal | Lab on a Chip |
| Volume | 13 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 7 2013 |
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ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- Chemistry(all)
- Biomedical Engineering
Cite this
External cavity laser biosensor. / Ge, Chun; Lu, Meng; George, Sherine; Flood, Timothy A.; Wagner, Clark; Zheng, Jie; Pokhriyal, Anusha; Eden, J. Gary; Hergenrother, Paul J.; Cunningham, Brian T.
In: Lab on a Chip, Vol. 13, No. 7, 07.04.2013, p. 1247-1256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - External cavity laser biosensor
AU - Ge, Chun
AU - Lu, Meng
AU - George, Sherine
AU - Flood, Timothy A.
AU - Wagner, Clark
AU - Zheng, Jie
AU - Pokhriyal, Anusha
AU - Eden, J. Gary
AU - Hergenrother, Paul J.
AU - Cunningham, Brian T.
PY - 2013/4/7
Y1 - 2013/4/7
N2 - Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser cavity, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity and large dynamic range. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors. This journal is
AB - Utilizing a tunable photonic crystal resonant reflector as a mirror of an external cavity laser cavity, we demonstrate a new type of label-free optical biosensor that achieves a high quality factor through the process of stimulated emission, while at the same time providing high sensitivity and large dynamic range. The photonic crystal is fabricated inexpensively from plastic materials, and its resonant wavelength is tuned by adsorption of biomolecules on its surface. Gain for the lasing process is provided by a semiconductor optical amplifier, resulting in a simple detection instrument that operates by normally incident noncontact illumination of the photonic crystal and direct back-reflection into the amplifier. We demonstrate single-mode, biomolecule-induced tuning of the continuous-wave laser wavelength. Because the approach incorporates external optical gain that is separate from the transducer, the device represents a significant advance over previous passive optical resonator biosensors and laser-based biosensors. This journal is
UR - http://www.scopus.com/inward/record.url?scp=84874828516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874828516&partnerID=8YFLogxK
U2 - 10.1039/c3lc41330f
DO - 10.1039/c3lc41330f
M3 - Article
C2 - 23429747
AN - SCOPUS:84874828516
VL - 13
SP - 1247
EP - 1256
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 7
ER -