Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes

C. Victor Jongeneel; Laurence Briant; Irina A. Udalova; André Sevin; Sergei A. Nedospasov; Anne Cambon-Thomsen

doi:10.1073/pnas.88.21.9717

Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes

C. Victor Jongeneel, Laurence Briant, Irina A. Udalova, André Sevin, Sergei A. Nedospasov, Anne Cambon-Thomsen

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Abstract

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-β gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-β gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

Original language	English (US)
Pages (from-to)	9717-9721
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	21
DOIs	https://doi.org/10.1073/pnas.88.21.9717
State	Published - 1991
Externally published	Yes

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Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. / Jongeneel, C. Victor; Briant, Laurence; Udalova, Irina A. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 21, 1991, p. 9717-9721.

Research output: Contribution to journal › Article › peer-review

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abstract = "We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-β gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-β gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.",

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AU - Jongeneel, C. Victor

AU - Briant, Laurence

AU - Udalova, Irina A.

AU - Sevin, André

AU - Nedospasov, Sergei A.

AU - Cambon-Thomsen, Anne

PY - 1991

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N2 - We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-β gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-β gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

AB - We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-β gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-β gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

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Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes

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