Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas.

Khawar Siddique, Niranjan Yanamandra, Meena Gujrati, Dzung Dinh, Jasti S. Rao, William Olivero

Research output: Contribution to journalArticle

Abstract

MMP-2, MMP-9, and uPA have been previously described as important to the invasive and metastatic potential of human tumors, including breast, lung, glioblastoma, and prostate. We examined the activity of these proteases and the levels of their inhibitors (TIMP-1 and TIMP-2) in a series of human meningioma tissue samples. Normal brain tissue did not show elevated levels of uPA, MMP-2 or MMP-9 activity. Meningiomas showed a mild, to moderate to significantly high level of uPA, MMP-2, and MMP-9. However, no increase in TIMP-1 or TIMP-2 levels was detected. Immunohistochemistry confirmed the assay findings and localized these molecules to the cell surface. The findings provide evidence for elevated levels of uPA and MMPs in meningiomas and suggest a therapeutic target for minimizing the malignant propensity of meningiomas using protease inhibitors.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalInternational journal of oncology
Volume22
Issue number2
DOIs
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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