Exposure to endocrine disruptors during adulthood: Consequences for female fertility

Saniya Rattan, Changqing Zhou, Catheryne Chiang, Sharada Mahalingam, Emily Brehm, Jodi A Flaws

Research output: Contribution to journalReview article

Abstract

Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence. This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals on fertility during adult life. The chemicals covered in this review are pesticides (organochlorines, organophosphates, carbamates, pyrethroids, and triazines), heavy metals (arsenic, lead, and mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate and bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, and parabens. This review focuses on the hypothalamus, pituitary, ovary, and uterus because together they regulate normal female fertility and the onset of reproductive senescence. The literature shows that several endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals.

Original languageEnglish (US)
Pages (from-to)R109-R129
JournalJournal of Endocrinology
Volume233
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Endocrine Disruptors
Fertility
Infertility
Parabens
Hormones
Triclosan
Anovulation
Plasticizers
Pyrethrins
Triazines
Carbamates
Estrous Cycle
Organophosphates
Polychlorinated Biphenyls
Arsenic
Menstrual Cycle
Heavy Metals
Mercury
Pesticides
Hypothalamus

Keywords

  • Adult
  • Endocrine disrupting chemicals
  • Female
  • Fertility

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Exposure to endocrine disruptors during adulthood : Consequences for female fertility. / Rattan, Saniya; Zhou, Changqing; Chiang, Catheryne; Mahalingam, Sharada; Brehm, Emily; Flaws, Jodi A.

In: Journal of Endocrinology, Vol. 233, No. 3, 01.06.2017, p. R109-R129.

Research output: Contribution to journalReview article

Rattan, Saniya ; Zhou, Changqing ; Chiang, Catheryne ; Mahalingam, Sharada ; Brehm, Emily ; Flaws, Jodi A. / Exposure to endocrine disruptors during adulthood : Consequences for female fertility. In: Journal of Endocrinology. 2017 ; Vol. 233, No. 3. pp. R109-R129.
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