Exploring the reversibility of the ring-closing metathesis mediated cross-linking of dendrimers

Ruthenium based catalysts have been employed for producing a diversity of compounds such as natural products, artificial polymers, and mechanically interlocked compounds. Macrocyclic system using the ring-closing metathesis (RCM) reaction, that includes metallomacrocycles, nanotubes, monomolecularly imprinted dendrimers (MIDs), and a triply threaded molecular bundle have been reported. The synthesis of Dendrimer 7 began by coupling mono-TBDMS-protected 1,1,1-tris(hydroxymethyl)ethane and G-3 acid chloride dendron 3 for producing dendrimer 4. More extensive dynamic molding and presumably structures that represent better the thermodynamic products, the second generation catalyst 2 is preferred as extensive dynamic molding can be achieved. This catalyst was avoided primarily as the higher activity has been made more difficult for making some inter-dendrimer reaction possible during the work-up.