TY - GEN
T1 - Exploring the prospects for a nanometer-scale gene chip
AU - Dimitrov, V.
AU - Aksimentiev, A.
AU - Schulten, K.
AU - Heng, J.
AU - Sorsch, T.
AU - Mansfield, W.
AU - Miner, J.
AU - Watson, G. P.
AU - Cirelli, R.
AU - Klemens, F.
AU - Bower, J.
AU - Ferry, E.
AU - Taylor, A.
AU - Kornblit, A.
AU - Dorvel, B.
AU - Zhao, Q.
AU - Timp, G.
PY - 2006
Y1 - 2006
N2 - We are exploring the feasibility of sequencing a single molecule of DNA using a revolutionary type of silicon integrated circuit that incorporates an on-chip nanopore mechanism with a molecular trap. The essential component is a single, nanometer-diameter pore in a robust, nanometer-thick membrane formed from a Metal Oxide Semiconductor (MOS) capacitor. To sequence the molecule, the voltage induced by the dipole moment associated with each base is measured using the electrodes on the capacitor as the DNA translocates through the pore.
AB - We are exploring the feasibility of sequencing a single molecule of DNA using a revolutionary type of silicon integrated circuit that incorporates an on-chip nanopore mechanism with a molecular trap. The essential component is a single, nanometer-diameter pore in a robust, nanometer-thick membrane formed from a Metal Oxide Semiconductor (MOS) capacitor. To sequence the molecule, the voltage induced by the dipole moment associated with each base is measured using the electrodes on the capacitor as the DNA translocates through the pore.
UR - http://www.scopus.com/inward/record.url?scp=46049116302&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46049116302&partnerID=8YFLogxK
U2 - 10.1109/IEDM.2006.346987
DO - 10.1109/IEDM.2006.346987
M3 - Conference contribution
AN - SCOPUS:46049116302
SN - 1424404398
SN - 9781424404391
T3 - Technical Digest - International Electron Devices Meeting, IEDM
BT - 2006 International Electron Devices Meeting Technical Digest, IEDM
T2 - 2006 International Electron Devices Meeting, IEDM
Y2 - 10 December 2006 through 13 December 2006
ER -