Abstract
In this study, a d-limonene nanoemulsion was developed by using a spontaneous emulsification method and its potential to inhibit the quorum sensing (QS)-regulated properties of Escherichia coli O157:H7 (E. coli) were revealed. The results in this study showed that d-limonene nanoemulsion inhibited E. coli biofilm formation through the suppression of curli and extracellular polymeric substance (EPS) production without inhibiting cell growth, and decreased swimming and swarming ability. Further analyses showed that d-limonene nanoemulsion interfered with auto-inducer 2 (AI-2) communication and repressed the expression of curli related genes and AI-2 importer genes in E. coli.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1979-1986 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 106 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2018 |
| Externally published | Yes |
Keywords
- AI-2
- Escherichia coli O157:H7
- biofilm
- d-limonene nanoemulsion
- quorum sensing
ASJC Scopus subject areas
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys
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