Exploring the anti-quorum sensing activity of a d-limonene nanoemulsion for Escherichia coli O157:H7

Renjie Wang, Pablo Vega, Yi Xu, Chin Yi Chen, Joseph Irudayaraj

Research output: Contribution to journalArticle

Abstract

In this study, a d-limonene nanoemulsion was developed by using a spontaneous emulsification method and its potential to inhibit the quorum sensing (QS)-regulated properties of Escherichia coli O157:H7 (E. coli) were revealed. The results in this study showed that d-limonene nanoemulsion inhibited E. coli biofilm formation through the suppression of curli and extracellular polymeric substance (EPS) production without inhibiting cell growth, and decreased swimming and swarming ability. Further analyses showed that d-limonene nanoemulsion interfered with auto-inducer 2 (AI-2) communication and repressed the expression of curli related genes and AI-2 importer genes in E. coli.

Original languageEnglish (US)
Pages (from-to)1979-1986
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume106
Issue number7
DOIs
StatePublished - Jul 2018
Externally publishedYes

Fingerprint

Escherichia coli
Genes
Emulsification
Biofilms
Cell growth
limonene
Communication

Keywords

  • AI-2
  • Escherichia coli O157:H7
  • biofilm
  • d-limonene nanoemulsion
  • quorum sensing

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

Exploring the anti-quorum sensing activity of a d-limonene nanoemulsion for Escherichia coli O157:H7. / Wang, Renjie; Vega, Pablo; Xu, Yi; Chen, Chin Yi; Irudayaraj, Joseph.

In: Journal of Biomedical Materials Research - Part A, Vol. 106, No. 7, 07.2018, p. 1979-1986.

Research output: Contribution to journalArticle

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