TY - JOUR
T1 - Exploration of the bicyclo[3.3.1]nonane system as a template for the development of new ligands for the estrogen receptor
AU - Muthyala, Rajeev S.
AU - Carlson, Kathryn E.
AU - Katzenellenbogen, John A.
N1 - Funding Information:
This research was supported by grants from the National Institutes of Health (PHS 5R37 DK15556).
PY - 2003/12/15
Y1 - 2003/12/15
N2 - Three novel structural motifs based on a bicyclo [3.3.1]nonane template were examined as new ligands for estrogen receptor (ER). Type III compounds emerged as the most promising leads for developing high-affinity ER ligands, but they showed little selectivity for either ER subtype. Type II compounds, on the other hand, despite their lower affinity, exhibited significant ERβ binding selectivity.
AB - Three novel structural motifs based on a bicyclo [3.3.1]nonane template were examined as new ligands for estrogen receptor (ER). Type III compounds emerged as the most promising leads for developing high-affinity ER ligands, but they showed little selectivity for either ER subtype. Type II compounds, on the other hand, despite their lower affinity, exhibited significant ERβ binding selectivity.
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U2 - 10.1016/j.bmcl.2003.08.061
DO - 10.1016/j.bmcl.2003.08.061
M3 - Article
C2 - 14643352
AN - SCOPUS:0345358448
SN - 0960-894X
VL - 13
SP - 4485
EP - 4488
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 24
ER -