Exploration of the bicyclo[3.3.1]nonane system as a template for the development of new ligands for the estrogen receptor

Rajeev S. Muthyala, Kathryn E. Carlson, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review

Abstract

Three novel structural motifs based on a bicyclo [3.3.1]nonane template were examined as new ligands for estrogen receptor (ER). Type III compounds emerged as the most promising leads for developing high-affinity ER ligands, but they showed little selectivity for either ER subtype. Type II compounds, on the other hand, despite their lower affinity, exhibited significant ERβ binding selectivity.

Original languageEnglish (US)
Pages (from-to)4485-4488
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number24
DOIs
StatePublished - Dec 15 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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