Exploiting genetic diversity by directed evolution: Molecular breeding of type III polyketide synthases improves productivity

Wenjuan Zha, Sheryl B. Rubin-Pitel, Huimin Zhao

Research output: Contribution to journalArticlepeer-review

Abstract

Applying directed evolution to the phloroglucinol synthase PhlD from Pseudomonas fluorescens Pf-5 has provided the first example of engineering enhanced productivity in a type III polyketide synthase, and a rare instance of improving the activity of a biosynthetic enzyme from secondary metabolism. This journal is

Original languageEnglish (US)
Pages (from-to)246-248
Number of pages3
JournalMolecular BioSystems
Volume4
Issue number3
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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