Experimental Validation of Perfusion Imaging with HOSVD Clutter Filters

Yang Zhu, Min Woo Kim, Cameron Hoerig, Michael F. Insana

Research output: Contribution to journalArticlepeer-review


Novel pulsed-Doppler methods for perfusion imaging are validated using dialysis cartridges as perfusion phantoms. Techniques that were demonstrated qualitatively at 24 MHz, in vivo, are here examined quantitatively at 5 and 12.5 MHz using phantoms with the blood-mimicking fluid flow within cellulose microfibers. One goal is to explore a variety of flow states to optimize measurement sensitivity and flow accuracy. The results show that 2-3-s echo acquisitions at roughly 10 frames/s yield the highest sensitivity to flows of 1-4 mL/min. A second goal is to examine methods for setting the parameters of higher order singular value decomposition (HOSVD) clutter filters. For stationary or moving clutter, the velocity of the blood-mimicking fluid in the microfibers is consistently estimated within measurement uncertainty (mean coefficient of variation = 0.26). Power Doppler signals were equivalent for stationary and moving clutter after clutter filtering, increasing approximately 3 dB/mL/min of blood-mimicking fluid flow for 0≤ q≤4 mL/min. Comparisons between phantom and preclinical images show that peripheral perfusion imaging can be reliably achieved without contrast enhancement.

Original languageEnglish (US)
Article number9075261
Pages (from-to)1830-1838
Number of pages9
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number9
StatePublished - Sep 2020


  • Color-flow (CF) imaging
  • phantom studies
  • power-Doppler (PD) imaging
  • ultrasound

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Experimental Validation of Perfusion Imaging with HOSVD Clutter Filters'. Together they form a unique fingerprint.

Cite this