Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa

Lawrence B Schook, L. Carrick, R. S. Berk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tracheal intubation of viable Pseudomonas aeruginosa into lungs of mice had no lethal effect on the animals. However, the treatment of animals with methotrexate, vincristine sulfate, or cytosine arabinoside simultaneously with the bacterial challenge into the lungs resulted in LD50 values of 4.1 x 107 CFU, 4.8 x 107 CFU, and 1.9 x 108 CFU, respectively.

Original languageEnglish
Title of host publicationIRCS Medical Science: Biochemistry
Volume4
Edition8
StatePublished - Dec 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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