Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa

Lawrence B Schook; L. Carrick; R. S. Berk

Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa

Lawrence B Schook, L. Carrick, R. S. Berk

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Abstract

Tracheal intubation of viable Pseudomonas aeruginosa into lungs of mice had no lethal effect on the animals. However, the treatment of animals with methotrexate, vincristine sulfate, or cytosine arabinoside simultaneously with the bacterial challenge into the lungs resulted in LD₅₀ values of 4.1 x 10⁷ CFU, 4.8 x 10⁷ CFU, and 1.9 x 10⁸ CFU, respectively.

Original language	English
Title of host publication	IRCS Medical Science: Biochemistry
Volume	4
Edition	8
State	Published - 1976
Externally published	Yes

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General Medicine

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title = "Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa",

abstract = "Tracheal intubation of viable Pseudomonas aeruginosa into lungs of mice had no lethal effect on the animals. However, the treatment of animals with methotrexate, vincristine sulfate, or cytosine arabinoside simultaneously with the bacterial challenge into the lungs resulted in LD50 values of 4.1 x 107 CFU, 4.8 x 107 CFU, and 1.9 x 108 CFU, respectively.",

author = "Schook, {Lawrence B} and L. Carrick and Berk, {R. S.}",

year = "1976",

language = "English",

volume = "4",

booktitle = "IRCS Medical Science: Biochemistry",

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T1 - Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa

AU - Schook, Lawrence B

AU - Carrick, L.

AU - Berk, R. S.

PY - 1976

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N2 - Tracheal intubation of viable Pseudomonas aeruginosa into lungs of mice had no lethal effect on the animals. However, the treatment of animals with methotrexate, vincristine sulfate, or cytosine arabinoside simultaneously with the bacterial challenge into the lungs resulted in LD50 values of 4.1 x 107 CFU, 4.8 x 107 CFU, and 1.9 x 108 CFU, respectively.

AB - Tracheal intubation of viable Pseudomonas aeruginosa into lungs of mice had no lethal effect on the animals. However, the treatment of animals with methotrexate, vincristine sulfate, or cytosine arabinoside simultaneously with the bacterial challenge into the lungs resulted in LD50 values of 4.1 x 107 CFU, 4.8 x 107 CFU, and 1.9 x 108 CFU, respectively.

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M3 - Chapter

AN - SCOPUS:0017154160

VL - 4

BT - IRCS Medical Science: Biochemistry

ER -

Experimental pulmonary infection of mice by tracheal intubation of Pseudomonas aeruginosa

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