Tracheal intubation of viable Pseudomonas aeruginosa ATCC 19660 into the lungs of mice had no significant effect on the animals even with administration of organisms as high as 5.0 x 109 CFU. Animals treated with a single injection of an antineoplastic drug were, however, susceptible to bacterial challenge into the lungs. LD50 values of 4.1 x 107, 4.8 x 107, and 1.0 x 108 CFU were obtained when animals were simultaneously infected and treated with methotrexate, vincristine sulfate, or cytosine arabinoside, respectively.
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Molecular Biology