Experimental and computational determination of tRNA dynamics

Rebecca W. Alexander, John Eargle, Zaida Luthey-Schulten

Research output: Contribution to journalReview article

Abstract

As the molecular representation of the genetic code, tRNA plays a central role in the translational machinery where it interacts with several proteins and other RNAs during the course of protein synthesis. These interactions exploit the dynamic flexibility of tRNA. In this minireview, we discuss the effects of modified bases, ions, and proteins on tRNA structure and dynamics and the challenges of observing its motions over the cycle of translation.

Original languageEnglish (US)
Pages (from-to)376-386
Number of pages11
JournalFEBS Letters
Volume584
Issue number2
DOIs
StatePublished - Jan 21 2010

Keywords

  • Conformational change
  • Flexibility
  • Induced fit
  • Molecular dynamics
  • Translation
  • tRNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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