Expanding the synthetic biology toolbox: Engineering orthogonal regulators of gene expression

Research output: Contribution to journalReview article


Despite substantial progress in synthetic biology, we still lack the ability to engineer anything as complex as Nature has. One of the many reasons is that we lack the requisite tools for independently controlling the expression of multiple genes in parallel. While our toolbox is still spare, the situation is rapidly changing. This opinion discusses some recent approaches and open challenges in designing orthogonal regulators of gene expression in bacteria.

Original languageEnglish (US)
Pages (from-to)689-694
Number of pages6
JournalCurrent Opinion in Biotechnology
Issue number5
StatePublished - Oct 1 2012


ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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