TY - JOUR
T1 - Expanding the cellular molecular chaperone network through the ubiquitous cochaperones
AU - Echtenkamp, Frank J.
AU - Freeman, Brian C.
PY - 2012/3
Y1 - 2012/3
N2 - Cellular environments are highly complex and contain a copious variety of proteins that must operate in unison to achieve homeostasis. To guide and preserve order, multifaceted molecular chaperone networks are present within each cell type. To handle the vast client diversity and regulatory demands, a wide assortment of chaperones are needed. In addition to the classic heat shock proteins, cochaperones with inherent chaperoning abilities (e.g., p23, Hsp40, Cdc37, etc.) are likely used to complete a system. In this review, we focus on the HSP90-associated cochaperones and provide evidence supporting a model in which select cochaperones are used to differentially modulate target proteins, contribute to combinatorial client regulation, and increase the overall reach of a cellular molecular chaperone network. This article is part of a Special Issue entitled: Heat Shock Protein 90 (HSP90).
AB - Cellular environments are highly complex and contain a copious variety of proteins that must operate in unison to achieve homeostasis. To guide and preserve order, multifaceted molecular chaperone networks are present within each cell type. To handle the vast client diversity and regulatory demands, a wide assortment of chaperones are needed. In addition to the classic heat shock proteins, cochaperones with inherent chaperoning abilities (e.g., p23, Hsp40, Cdc37, etc.) are likely used to complete a system. In this review, we focus on the HSP90-associated cochaperones and provide evidence supporting a model in which select cochaperones are used to differentially modulate target proteins, contribute to combinatorial client regulation, and increase the overall reach of a cellular molecular chaperone network. This article is part of a Special Issue entitled: Heat Shock Protein 90 (HSP90).
KW - Cdc37
KW - Cochaperone
KW - Hsp90
KW - Large immunophilin
KW - Molecular chaperone
KW - P23
UR - http://www.scopus.com/inward/record.url?scp=84857058279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857058279&partnerID=8YFLogxK
U2 - 10.1016/j.bbamcr.2011.08.011
DO - 10.1016/j.bbamcr.2011.08.011
M3 - Article
C2 - 21889547
AN - SCOPUS:84857058279
SN - 0167-4889
VL - 1823
SP - 668
EP - 673
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 3
ER -